Single Nucleodtide Polymorphisms or snips are variations in genetic nucleotide sequences that are associated with almost all diseases. These gentitic variations form proteins that have abnormal shapes making them unable to key and lock in normal functional responses.

Folic acid metabolism has been studied with this model in mind.

Poor Folic acid metabolism is seen in many diseases such as spina bifida and other neural tube defects in pregnancy; depression, anxiety and obsessive compulsive disorder; Alzheimers, dementia and cognitive decline; heart disease and stroke; cancer; rheumatoid arthritis and osteoarthritis; and general inflammatory conditions.

A significant portion of the population has difficulty in metabolizing and utilizing folic acid in the body due to polymorphisms or snips related to folate metabolism. Bioactive folate, a circulating form of folate, bipasses these snips and provides bio available folate. This form is called L-5 methyl tetrahydrofolate.